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Oxidative mechanisms may also regulate GPx-1 gene transcription via nuclear factor B (NFB) sites and activator protein 1 (AP-1) sites in the promoter
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Epithalon activates the Nrf2 pathway, which regulates the production of the bodys intrinsic antioxidant enzymes including superoxide dismutase, glutathione peroxidase, and catalase
This decision will depend largely on the type of benefits provided by the combination therapy, which could include a greater degree of response, an increase in the proportion of patients who respond, a faster or more durable response, as well as a better tolerability and adverse event profile 57
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