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The market potential is enormous, given that MASLD affects roughly 30% of adults globally

The drugs work by triggering hormones in the brain which trick the body into slowing digestion and keeping the stomach full, reducing appetite, and consequently, the amount people eat

This introduces variability in pharmacodynamics, as GLP-1RA penetration into specific brain regions may differ based on sex, compound properties, and age ( This raises important questions for ongoing trials such as EVOKE, which may uncover sex-specific differences and justify subsequent investigations of GLP-1 analogues in female populations