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Histopathological examination of kidney tissues Kidney tissues were used for histopathological studies, as was formerly defined by Culling [31]

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While overall decline rates were similar between groups, post-hoc subgroup analysis indicated slower cognitive decline in early-onset patients (aged 65 or younger) compared to placebo, as measured by the Alzheimer's Disease Assessment Scale cognitive subscale and Clinical Dementia Rating Scale [5][18]

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