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In the liver, it increases insulin sensitivity and reduces fat accumulation

During bovine and porcine oocyte maturation, metformin is able to impede meiotic progression ( In a mouse model of PCOS, metformin treatment was explored to alleviate the negative influence of hyperandrogenism on oocyte quality ( in vitro fertilization of oocyte-specific AMPK KO mice, a 68% reduction in the number of embryos passing the 2-cell stage was observed ( Mouse embryos exposed to metformin from the 2-cell to the blastocyst stage in vitro are smaller in size with lower cell numbers ( In vivo , metformin reduced apoptosis in blastocysts of obese mice ( Metformin and male reproductive biology In males, metformin is prescribed for the treatment of T2DM