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Collectively those papers are conflicting but four out of five of them (Brandalize et al., Despite that a meta-analysis of the few studies of DS-CHD is yet not possible due to their relatively small number (Table 4), a recent meta-analysis of 18 case-control studies, that included data from 18.500 cases of CHD, revealed that maternal folic acid supplementation is associated with a significant decreased risk of CHD (OR: 0.72, 95%CI: 0.630.82), and the association remained significant even after stratification of the data into CHD subtypes (Feng et al., 2015)

PMID: 6244017

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