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Access this article Similar content being viewed by others Abbreviations ALCAR: Acetyl-l-carnitine OCTN2: Organic cation transporter novel 2 CPT I: Carnitine palmitoyltransferase I CPT II: Carnitine palmitoyltransferase II CAT: Carnitine acetyltransferase MRS: Magnetic resonance spectroscopy 13 C-NMR: 13 C-nuclear magnetic resonance spectroscopy OGD: Oxygen-glucose deprivation HI: Hypoxia-ischemia TBI: Traumatic brain injury 3-NPA: 3-nitropropionic acid i.p.: Intraperitoneal CSF: Cerebrospinal fluid mTOR: Mammalian target of rapamycin NGF: Nerve growth factor pNFH: Phosphorylated high-molecular weight neurofilament rCMRglc: Cerebral regional metabolic rate of glucose TBI: Traumatic brain injury TCA: Tricarboxylic acid References Jones LL, McDonald DA, Borum PR (2010) Acylcarnitines: role in brain

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On this basis, the presence of microvascular alterations in a pre-diabetic mouse model also suggests that early hyperinsulinaemia and insulin resistance are sufficient to induce vascular damage and that bloodbrain barrier dysfunction precedes cognitive decline (25)