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Indications include: Medically refractory disease not responding to optimized biologic therapy Bowel obstruction from fibrostenotic stricture Intra-abdominal abscess not amenable to percutaneous drainage Complex perianal fistula (seton placement, diversion) Enterocutaneous or enterovesical fistula Dysplasia or cancer in Crohns colitis Free perforation (rare) Nutritional Therapy Exclusive enteral nutrition (EEN) effective for induction in pediatric Crohns

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Thus, while it is critical to define subpopulations at higher risk of serious disease from a threatening virus (e.g., the elderly, persons with diabetes, etc.), it is equally important to define subpopulations with an elevated risk of adverse vaccination effects