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Earlier evidence for retatrutide comes from a Phase 2 trial in NEJM in 2023, which reported 24.2% weight loss at 12 mg over 48 weeks
doi: 10.1038/379069a0 54 BarreraJGJonesKRHermanJPDAlessioDAWoodsSCSeeleyRJ
Medical therapies commonly include progestins, GnRH agonists, and oral contraceptives, which can alleviate symptoms to some extent but often cause significant side effects and tend to relapse once the medication is discontinued
If you look at the anti-doping statistics and the number of reported positives over the last decade there have been only a handful of positive drug tests across all these substances combined
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