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The pre-specified secondary outcomes were (1) all cause-mortality and (2) incidence of a cardiovascular composite event outcome that included: first occurrence of acute myocardial infarction, cardiac arrest or ventricular fibrillation, acute stroke, or coronary revascularization, as previously described and validated using validated International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) and 10th Revision, Clinical Modification (ICD-10-CM) and procedure codes 52,53,54

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All parameters were measured continuously and simultaneously for three weeks after initiation of the treatment, only briefly paused for a weekly calibration and retrieval of the generated data

Notably, 45.3% of the high-dose group achieved over 30% weight loss, paralleling results often achieved by bariatric surgery