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While valproate predictably reduced the expression of the pkc substrate MARCKS, it enhanced the expression of gap-43 concurrent with increased neurite outgrowth

Hence, contrary to the expectation that hematopoietic progenitors would be geno-protected throughout life, we found that progenitor cells from aged killifish carry higher levels of DNA damage compared to all other cell types in the hematopoietic organ, as recently shown in aged mammalian HSCs 77,78 , and to some extent, in aged-adult humans 79

However, this does not mean we can automatically promise that CJC-1295 will: Build muscle. Melt belly fat. Reverse aging. Or: Transform your body composition. Those are much stronger clinical claims

10.1038/s41598-023-35896-w 68 GostnerJ