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In fact, some researchers are proposing that GLP-1 and related drugs are the most important drug-class breakthrough in medical history. 2 There is one simple but intriguing question about this whole topic: How can one drug have so many seemingly unrelated benefits

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They reported that caerulein administration activated the pancreatic mechanistic target of rapamycin (mTOR), increased phosphorylated TFEB levels, and accelerated TFEB degradation, ultimately reducing TFEB abundance and the number of lysosomes

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