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reuteri ATCC PTA 6475 has been successfully engineered into a recombinant strain capable of secreting IL-22 [195], which achieves in situ delivery of the cytokine in the intestinal tract through the high-copy plasmid pJP028, demonstrating superior lipid-lowering effects in NAFLD models compared to the wild-type strain

Imaging data from cultured neonatal rat hippocampal neurons indicate that Nle-AngIV stimulates dendritic spine numbers and size, as well as overall dendritic arborization, suggesting a plausible mechanism for enhanced synaptic plasticity, connectivity among neurons, and facilitation of memory [28]

Proc R Soc B 286(1912):20191718

doi: 10.1055/s-0029-1243121