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It works through AMP-activated protein kinase (AMPK) activation, which actually shares some mechanistic overlap with ketosis

36 Along these lines, maintaining weight loss is a common issue after halting GLP-1RA treatment, which raises concerns about the longevity of the treatment efficacy, especially considering the high financial cost to the patient

Without these, reduced appetite becomes a liability rather than an asset

Binge Eating Disorder The safety data in this section is based on data from two 12-week parallel group, flexible-dose, placebo-controlled studies in adults with BED [see Clinical Studies 14.2]