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Cell culture applications utilize concentrations of 10-50 M for effective senescent cell elimination, with administration durations typically 24-72 hours depending on experimental objectives and cellular models

Numerous research results have shown that TMAO not only participates in the pathophysiological progression of heart and renal diseases but also significantly affects outcomes in chronic heart failure (CHF) and chronic kidney disease (CKD), besides influencing the general health of populations

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