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Although the overall disease progression of NAFLD has been characterized, the exact mechanism(s) underlying its initiation and progression remain poorly defined

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The number of self-reported current somatic diseases (including cardiometabolic, respiratory, musculoskeletal, digestive, neurological, endocrine diseases and cancer) for which participants received medical treatment was counted (coded as 0, 1, 2+) as a global marker of poor physical health

Conclusion: NGT carriers of the T2D-associated genetic variant rs111669836 are characterised by diminished incretin effect and low OGTT-induced GLP-1 secretion whereas carriers of the rs17791513 G allele have significantly higher incretin effect and lower BMI than non-carriers