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The American Diabetes Association does not advocate for routine calcitonin screening due to concerns about false-positive results, low positive predictive value, and potential for unnecessary interventions

It differs from the modest lean-mass reduction seen during weight loss, where the body adapts to lower energy needs

GLP-1s are unique in how quickly and dramatically appetite can decrease, often faster than a person's ability to consciously shift toward more nutrient-dense foods

However, the current evidence base is limited by small sample sizes, heterogeneous study populations, and a paucity of randomized controlled trials in non-diabetic psychiatric cohorts