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Cost-effectiveness Cost-effectiveness continues to be a key issue, as the raw materials (such as high-purity phospholipids and cholesterol), sterile manufacturing facilities, and specialised machinery considerably increase production costs relative to traditional formulations

Free radicals are highly reactive molecules produced by environmental factors or normal metabolism that can damage skin cells and tissues and lead to oxidative stress

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ROS produced by NADPH oxidase activity was related to chemokine (CCL2, CXCL8, and CXCL10) production, and it was inhibited by the treatment of astrocytes with NAC or NADPH oxidase inhibitors [58]