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In a study of patients transitioning from injectable semaglutide to the oral formulation, 50% reported higher satisfaction with the pill, while the remaining 50% either preferred the injection or remained indifferent

These findings are consistent with human postmortem studies [78]

Thus, considering evidence documenting the existence of various GLP-1-producing subpopulations of alpha-cells in the adult pancreas, these results would indicate that a range of alpha-cell maturity exists within the adult pancreas

Semaglutide exposure in patients with mild and moderate renal impairment was similar to that in patientswith normal renal function