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The FDA's standard review period for a Priority Review designation is six months

Large cardiovascular outcome trials show reduced cardiovascular events despite small heart rate increases

After 36 weeks, the 0.5 mg retatrutide group showed a 3.19% body weight reduction, the 4 mg group showed a 10.37% decrease, the 8 and 12 mg groups demonstrated decreases of 16.81% and 16.94% respectively, which were significantly greater than those observed with placebo (3.00%) and 1.5 mg dulaglutide (2.02%) [114]

He speculates that GLP-1 receptors in some people may have genetic differences that might influence how well the hormone binds to the receptor and activates subsequent insulin and satiety pathways