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Critical Reviews in Eukaryotic Gene Expression 20:87103

Unlike earlier treatments that targeted only one hormone, Mounjaro works through a dual mechanism , activating: GLP-1 (Glucagon-Like Peptide-1) GIP (Glucose-dependent insulinotropic polypeptide) These peptides play an essential role in regulating: appetite and satiety insulin production blood sugar control fat metabolism energy balance By influencing both pathways simultaneously, tirzepatide helps reduce hunger while improving metabolic regulation

This shift places intense pressure on trial design, endpoints, and execution particularly in high-competition therapeutic areas such as oncology, neurology/CNS, cardiometabolic disease, and immunology