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Figure 10 Figure 11 Discussion By employing high-linear energy transfer (high-LET) 12 C 6+ heavy-ion irradiation, we established two stable BHK-21-derived clones with diametrically opposed foot-and-mouth disease virus (FMDV) susceptibilities: BHK-7 (markedly enhanced viral replication) and BHK-5 (highly antiviral to infection)