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Treatments tailored toward the needs of individual patients based on their CKD stage and microbiome profiles via the application of different -omics approaches such as microbiome analysis, metabolomics, metagenomics, metaproteomics, nutrigenomics, and others enable the application of suitable dietary requirements, physical activity, and/or biotic supplementation that will be most beneficial to them via modulation of the microbiota, reduction of uremic toxins and inflammation, and slowing CKD progression ultimately leading to an improvement in their cognitive health and overall quality of life

In addition, increasing abilities by creating a new field of synthetic biology opens additional opportunities in designing microorganisms with inherent therapeutic properties [114]

111 Therefore, abnormal Hippo/YAP pathways may be the potential pathogenesis of IR and other metabolic disease (Fig

Int J Mol Sci 2022;23:6857