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The dual GLP-1 and GIP activation also influences the hypothalamus, the brain region controlling temperature regulation, potentially amplifying cold sensitivity during early treatment phases

Additionally, patients using both treatments may attribute weight loss or adverse effects to the wrong agent, complicating clinical assessment

S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca2+ sensitivity in rat fast-twitch muscle fibers