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Research findings indicate that administration of A-1155463 led to an increase in apoptosis among senescent cells while inhibiting tumor growth by more than 2.5 times compared to proliferating tumors and nearly twice as much compared to tumors treated only with the senescence inducer CCC-021-TPP [107]

The Phase 2 trial showed that participants at 8mg achieved an average of 22.8% body weight reduction at 48 weeks

FDA status: Investigational New Drug, without marketing authorization

In addition, it is more effective to treat center-involved diabetic macular edema than photocoagulation surgery and has become the first-line therapy for diabetic macular edema