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Dual GLP1 and GIP agonists Tirzepatide is a once weekly, subcutaneous, unimolecular dual RA (GLP-1 and GIP) which has comparable GIP receptor binding affinity to native GIP and 5 times lower GLP-1 receptor affinity than that of native GLP-1

[5] All patients should be monitored for acute kidney injury, especially if dehydration occurs

In addition, T2DM is associated with an increased risk of stroke and mortality after stroke (79)

Clinical evidence supporting the renoprotective effects of incretin receptor agonists primarily derives from large cardiovascular outcome trials, where kidney outcomes were secondary endpoints