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Taken together, the LAG-1 AID time course results supports the findings from the initial genome-wide analysis that lst-1 and sygl-1 are likely the only two mRNA transcriptional targets of GLP-1 signaling in the germline
Thus, this underscores the need for next-generation subunit vaccines that elicit durable humoral and cellular immune responses ( Subunit vaccines, despite their excellent safety profile, often require potent adjuvants to enhance immunogenicity and achieve a sustained protective response against intracellular pathogens ( Recently, the role of B cells as non-canonical APCs has been recognized as crucial in prolonging the immunity following the repeated immunization ( Collectively, the present work explored the potential of a dual-adjuvant approach to induce durable and functionally active antigen-specific humoral responses against two pivotal Plasmodium liver-stage antigens, Pf CSP and Pb SLTRiP ( Materials and methods BALB/c and C57BL/6 mice, aged 68 weeks, were procured from Zydus Research Centre, Ahmedabad, India
10.1021/bi00857a007 Biochemistry 46 LindstedtG.LindstedtS
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