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Bulletin of Experimental Biology and Medicine 174(5): 693698

Individual outcomes vary, but improvement can be felt by most users after 2-4 weeks of continuous application

Studies have found that berberine attenuates ischemia-reperfusion injury through NF-B nuclear translocation in mice with transient cerebral artery occlusion, however, this neuroprotective effect was more pronounced at the high dose (50 mg/kg) than the low dose (25 mg/kg) (Zhu et al., 2018)