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The squares represent the effect sizes and the bars represent the 95% confidence interval

The gradual dose escalation protocol specifically aims to minimize these effects while building therapeutic benefit

Regarding weight loss, the FDA has approved these drugs for people whose body mass index (BMI) is greater than 30 kg/m2, or they have a BMI that is greater than 27 and have a weight-related health problem, such as high blood pressure, sleep apnea, or pre-diabetes

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