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Constipation is a recognised side effect, affecting up to 1 in 10 patients, primarily due to slowed gastric emptying and reduced gastrointestinal motility

La sibutramina formaba parte de la composicin de medicamentos con receta destinados al tratamiento de la obesidad, sin embargo, se suspendi su comercializacin en la Unin Europea por asociarse su consumo a efectos adversos graves de tipo cardiovascular, tal como se refleja en la nota informativa de la AEMPS sobre sibutramina (Reductil), publicada el 21 de enero de 2010

However, the structure of the Fab 3F52/ECD complex revealed a broader overlap between the two ligands which extends outside the ECD binding site