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Compare this to typical diet-only approaches where lean mass loss can account for 30-40% of total weight reduction, and the advantage becomes clear for anyone prioritizing muscle retention during their cut

In addition, GLP-1s can impact substance or alcohol use disorder and Prader-Willi syndrome through their effect on satiety hormones

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However, oral semaglutide (Rybelsus) increases levothyroxine exposure by approximately 33% according to FDA labeling, and all semaglutide formulations slow gastric emptying, potentially affecting levothyroxine absorption