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LDL circulating in the plasma appears to be protected from oxidation, both by dietary antioxidants such as vitamin E and C (259) and by protective enzymes including glutathione peroxidases (260,261), peroxiredoxins, PAF-acetylhydrolase (also known as lipoprotein-PLA2) (262,263), and paraoxonases (PON) (264,265)

Fortin & Roitman, 2017)

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If you follow a gradual dose escalation protocolstarting at 0.25 mg weekly and increasing every 4 weeksyou may experience brief episodes of loose stools at each step up