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Many prescribe other brands of semaglutide, such as Ozempic and Rybelsus, off-label (using a drug that is FDA-approved for a different reason)

Semaglutide is primarily degraded by proteolytic enzymes rather than hepatic cytochrome P450 enzymes, which are responsible for metabolising many medications, including warfarin

Additional monitoring is required for patients with diabetic retinopathy, and there is a potential risk of gallbladder disease with treatment