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Patients with significant renal or hepatic impairment, active malignancy, or uncontrolled cardiovascular disease should discuss suitability with their physician before starting

Moreover, in the CREDENCE trial, canagliflozin also did not cause an increase in amputations in the patients treated with the SLGT2 inhibitor (154)

Canadian Access and Considerations Canadian researchers and individuals interested in these compounds face a specific regulatory landscape that differs from other jurisdictions