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More importantly, using HSP90 conjugated with a fluorescent probe, it has been observed that extracellular HSP90 (eHSP90) binds HSP90i and further mediates inhibitor internalization [16,17,18,19]

Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation

PMID 15792952

Olson Frontiers in Bioengineering and Biotechnology doi 10.3389/fbioe.2023.1193454 6,368 views 5 citations Original Research Published on 04 Apr 2025 Enhancing therapeutic antibody production through amino acid-induced pH shift in Protein A affinity chromatography in Industrial Biotechnology Senzhu Lin Yue Wang Frontiers in Bioengineering and Biotechnology doi 10.3389/fbioe.2025.1567923 7,184 views 3 citations Original Research Published on 12 May 2023 Enhancing the therapeutic activity of hyperimmune IgG against chikungunya virus using FcRIIIa affinity chromatography in Molecular Innate Immunity Julie M