The decrease in TFRC expression, encoding the transferrin receptor [35], may reduce cellular iron uptake, potentially protecting against iron-mediated oxidative damage
The development of oral formulations, exemplified as oral semaglutide, signifies a notable progress in delivery techniques (Ke et al
RCT conducted in patients with T2D showed that high doses of tirzepatide represent the most efficacious incretin-based anti-diabetes drug in terms of BW reduction 33 , sustaining the development of the SURMOUNT program to explore its efficacy and safety in the management of obesity 9
However, excess or chronic inflammation causes many adverse health effects including fatigue, joint pain, digestive issues, anxiety and increased risk of developing cancer, heart disease, diabetes, and Alzheimers in the future