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In these situations, the presence of marked cytologic atypia, nuclear pleomorphism, increased cellular density, increased mitoses including atypical forms, clear demarcation from surrounding populations of benign-appearing melanocytes, and necrosis all point toward the diagnosis of melanoma

Int J Mol Sci 21(4):1275 Gamret AC, Price A, Fertig RM, Lev-Tov H, Nichols AJ (2018) Complementary and alternative medicine therapies for psoriasis: a systematic review