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An abundance of erythrocytes affects the rheological properties of blood, exponentially increasing the viscosity [49]

Several large-scale clinical trials and post-marketing surveillance studies have reported higher rates of cholelithiasis (gallstones) and cholecystitis (gallbladder inflammation) among patients treated with GLP-1 agonists compared to placebo or other glucose-lowering medications

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This is one of the key drivers of mitochondrial failure, accumulation of irreparable DNA damage and cellular aging across tissues