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If irritation continues to occur, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use

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Importantly, they also illustrate how defects at distinct levels of the UPS, substrate recognition, ubiquitin recycling or proteasome targeting, can converge on a common outcome of proteotoxic stress and neurodegeneration

ADA Standards of Care 2025 support CGM across a broader clinical spectrum, while Medicare criteria now cover all insulin-treated patients and certain non-insulin patients with documented problematic hypoglycemia