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10.1016/j.arr.2020.101191 Ageing Res

Current treatments primarily aim to restore dopaminergic signaling through levodopa, anticholinergic agents, and dopamine receptor agonists (Armstrong and Okun, 2020)

Inhibition of Xc - -mediated cystine uptake, which impairs GSH synthesis, is the primary mechanism of erastin-induced ferroptosis

Combination therapies, or single agents with pleiotropic actions, are increasingly being explored to interrupt the pathological cascade at multiple levels