semaglutide for alcohol JAMA - Most viewed this week from JAMA Psychiatry: Low-dose reduced craving and consumption in adults with alcohol use disorder. https://ja.ma/3Zlxi1c GLP-1 reduces heavy drinking days

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Oxyntomodulin is a biased agonist relative to GLP-1 1,3 (and exendin-P5 26 ), with a bias towards arrestin recruitment over cAMP production, which would compete for G protein interactions and may contribute to the lack of correlation between the faster G s dissociation and enhanced efficacy when assessing cAMP accumulation in whole cells over an extended timeframe