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Purified complexes (Supplemental Figure 1) that contained all expected components were vitrified and imaged by single particle cryo-EM on a 300kV Titan Krios, with (oxyntomodulin) or without (exendin-4) a Volta Phase Plate (VPP)

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Therefore, GLP-1 analogues have been found to have several non-glycaemic effects including improved blood pressure through arterial vasodilation and increased renal natriuresis and reduced appetite via delayed gastric emptying and centrally mediated satiety within the hypothalamus