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NAC Side Effects Side effects of NAC are generally mild and commonly include: Diarrhea Nausea Vomiting Skin rash Tiredness In some cases more serious side effects such as persistent headaches, low blood pressure and asthma attacks can occur, but these side effects are rare

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Blood and tissue distribution After transfer into blood, lipophilic Tac is mainly bound to red blood cells through the FK506 binding proteins (FKBP), leading to a 4-114-fold higher Tac concentration in full blood compared to plasma ( Because Tac binding to red blood cells is temperature sensitive as well as nonlinear, and the uptake by red blood cells is strongly dependent on FKBP concentration, it is practically difficult to separate full blood from plasma Tac ( 1 -acid glycoprotein, and globulins, whereas the unbound fraction is mainly responsible for therapeutic effects ( As expected, whole blood concentration of the clinically relevant unbound fraction is strongly dependent to hematocrit and albumin levels