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Across over 12,000 measured metabolic features, we observed a large discrepancy (73.54%) in the serum metabolome between BD patients and HCs, spotting differentially abundant microbial-derived neuroactive metabolites including multiple B-vitamins, kynurenic acid, gamma-aminobutyric acid and short-chain fatty acids

These responders approached bariatric surgery-level results using a once-weekly injection, fundamentally changing whats possible with pharmaceutical intervention

by contrast, antagonizing NMDA receptors in the hypothalamus has been linked to a reduction in food intake and a decrease in body weight 8

This differs fundamentally from the chaotic, leaky vessels tumors create to sustain their growth