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Weight Loss and Metabolic Factors Behind Blood Pressure Changes A significant portion of blood pressure reduction with GLP-1 therapy occurs through weight loss and accompanying improvements in insulin sensitivity and lipid profiles

In our early studies we found that millimolar levels of homocysteine decreased GPx1 mRNA levels in endothelial cells [58]

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[5] [4] Elevated homocysteine has been associated with cardiovascular concerns, though the clinical significance of supplementation remains under investigation