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Summary: GLP-1/GIP medicines (such as semaglutide and tirzepatide) are diabetes and weight management treatments that may indirectly affect vitamin B12 levels through altered gastric function, reduced dietary intake, and interaction with concurrent metformin use

A meta-regression analysis of GLP-1RA CVOT showed that the magnitude of HbA1c lowering, but not body weight (BW) loss, was associated with the prevention of renal outcomes [24]

This could be because those with obesity had a more difficult time obtaining insurance benefits for these expensive medications

Some researchers lose 2-5 pounds during this period, primarily from reduced caloric intake and water loss