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Why Semaglutide and Tirzepatide Can Cause Fatigue Medications like semaglutide and tirzepatide belong to a class of drugs known as GLP-1 receptor agonists

It works by mimicking a hormone called GLP-1, which regulates insulin production, slows digestion, and helps reduce food intake

The study demonstrated that glycine supplementation enhanced anabolic pathways while simultaneously reducing catabolic pathways, creating a favorable environment for muscle preservation even under conditions of metabolic stress

Peripheral effects on metabolism may include influences on insulin sensitivity, glucose metabolism, and adipocyte (fat cell) function