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Evolution of Genomic and T-cell Repertoire Heterogeneity of Malignant Pleural Mesothelioma Under Dasatinib Treatment

[DOI] [PubMed] [Google Scholar] 81.Risbud M.V., Bhonde R.R

Notably, the ferroptosis inhibitor Ferrostatin-1 exacerbated CGAs toxicity, while the inducer Erastin attenuated it (Supplementary Figure S2C), suggesting that the profound iron deficiency we describe disrupts fundamental metabolism in a manner distinct from, and prior to, the execution of classical ferroptosisa pathway CGA has been shown to inhibit in other contexts via Nrf2/GPX4 activation (Yang et al., 2025)

Regardless of treatment, whole blood GPx activity increased from day 0 to 28 ( P = 0.01) and decreased from day 28 to 56 ( P = 0.02) to be similar to day 0 at day 56 (Figure 2A)