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Preclinical and clinical studies have demonstrated that GLP-1 receptors expressed in myocardial and vascular endothelium tissue play a fundamental role in the cardioprotective effect of GLP-1 RAs, lowering the risk of major cardiovascular events, heart failure, and kidney complications in adults with and without diabetes [4]

In all, mouse and rat models have significant limitations for the studies regarding CTSs, their effect on humans and their role in the pathogenesis of human diseases

Anti-inflammatory properties: Reduces chronic low-grade inflammation, which causes skin thinning, loss of suppleness, and age-related tissue breakdown

Cell proliferation and clonogenic assays The TACS XTT cell proliferation assay kit (Trevigen) was used for cell proliferation assays as described previously