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A solution to induce an acute hepatic toxicity and a rapidly progressing encephalopathy with severe seizures in rats may be a single paracetamol overdose (5 g/kg intraperitoneally) that excided the regimens previously used (1, 2, 6, 11)
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FOXO4-DRI is a D-retro-inverso peptide, meaning its amino acid sequence is reversed and uses mirror-image D-amino acids, making it resistant to enzymatic degradation while maintaining binding activity
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