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4 Immunohistochemistry of interleukin-6 (IL-6) in the dorsal root ganglion (DRG) and spinal cord (SC) at phases (A) 1 and (B) 2 Graph (bottom) represents the number of immunostained cells in the DRG and SC (mean SD)

Baseline biomarkers such as malondialdehyde (MDA), glutathione peroxidase (GPx) activity, or inflammatory markers like CRP can help guide whether glutathione supplementation is clinically justified

Natural extracts like Cerebrolysin offer complexity

Additionally, E2 is known to be able to signal through the insulin-like growth factor 1 receptor (IGF-1R) in the skin in a non-genomic manner and this process has been implicated in the regulation of cutaneous aging (Serizawa et al., 2017)